ZPT, Climbazole and PO(OCTO) are the most commonly used anti-dandruff materials on the market at present, we will learn them from several dimensions:
1. Anti-dandruff basic
ZPT
It has a strong antibacterial ability, can effectively kill the dandruff-producing fungi, with a good dandruff function
Climbazole
It has unique anti-fungal properties, and has obvious inhibitory and killing effects on fungi, especially on the fungi causing human dander, the mechanism of removing dandruff and antipruritic is to eliminate the external factors of dandruff by sterilization and bacteriostasis, so as to achieve the effect of removing dandruff and antipruritic
PO
By sterilization and anti-oxidation, the external channel of dandruff is fundamentally blocked, so as to effectively cure dandruff and relieve itching, instead of removing dandruff temporarily from the surface by degreasing. This is OCTO antidandruff antipruritic performance superior to similar products one of the reasons
2. Solubility
ZPT
It is very difficult to dissolve in organic solvent and water, so it is not suitable to prepare transparent shampoo
Climbazole
Easy to dissolve in toluene, alcohol, difficult to dissolve in water
OCTO
Soluble in ethanol (10%) , water or ethanol/water mixture containing Surfactant (1%-10%) , slightly soluble in water (0.05%) and oil (0.05%-0.1%)
3. Blend with cosmetic ingredients
ZPT
It is incompatible with EDTA and will be less active in the presence of Surfactant and therefore can not be prepared in isolation from EDTA and Surfactant.
Climbazole
Compatible with cationic, anionic, and nonionic Surfactant
OCTO
Octo can be combined with a variety of cationic Surfactant and cationic active components, and this combination can also increase its solubility. The compatibility of Octo is superior to other antipruritic agents such as ZPT, MDS, CLM, etc.
4. Stability
ZPT
Better thermal stability, will have light scattering, using it to prepare shampoo has a certain extinction effect, product pearlescent effect will be affected. In addition, sedimentation often occurs in shampoo formulations, and it is easy to change color in the presence of iron ions. Suspension and stabilizer must be added. Ordinary metal and stainless steel equipment can not be used when ZPT is used, enamel or 316L equipment shall be used
Climbazole
For light and heat stability, in acidic and neutral solution can be stable existence, with its preparation of shampoo will not produce precipitation, stratification, color change
OCTO
Octo has good thermal stability; under direct UV light, Octo's active components will decompose, so it should be stored away from light as far as possible. Encounter copper and iron and other metals will change color, but the color is light yellow
5. Safety and irritability
ZPT
It has certain stimulation to the skin, the eye stimulation is bigger, if not careful will ZPT deep into the eyes, immediately with a large amount of water can be cleaned. It is safe within the recommended dosage
Climbazole
High Safety and no stimulation
OCTO
It is very reliable for eyes and skin. Non-toxic, irritant and allergenic.
6. Amount added
ZPT
0.5%-2.0%
Climbazole
0.4%-0.8%
OCTO
0.1%-0.75%
Post time: Mar-16-2022